Metabolic & longevity

Berberine is closer to a drug-like supplement: promising metabolic trials, but not casual candy - CYP interactions and GI effects matter.

Algal omega-3 (vegan DHA/EPA) is commonly associated with: vegan dha/epa; pregnancy vegetarian. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Beetroot nitrate (concentrate / juice) is commonly associated with: endurance / bp acute effects. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Beta-carotene (isolated) is commonly associated with: vitamin a precursor; antioxidant era trials. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Betaine (trimethylglycine) is commonly associated with: homocysteine niche; power output small trials. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

CDP-choline (citicoline) is commonly associated with: stroke recovery research (regional); cognition marketing. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Choline sits between diet adequacy and nootropic marketing depending on form and dose.

Citrulline malate is commonly associated with: blood flow / endurance marketing; arginine precursor. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

CoQ10 is biologically plausible and sometimes clinically used as an adjunct; outcomes vary widely by indication and study quality.

Coenzyme Q10 (ubiquinone / ubiquinol) is commonly associated with: statin-associated symptoms (mixed trials); heart failure adjunct in some guidelines contexts. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Curcumin is mechanistically interesting and sometimes clinically useful for specific pain/inflammation contexts, but it is not a universal anti-inflammatory drug replacement.

Flaxseed oil (ALA) is commonly associated with: plant omega-3 source. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Inositol is not insulin for PCOS.

L-Arginine (AKG / HCl forms) is commonly associated with: nitric oxide marketing; erectile function (modest vs pde5i). Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

L-Carnitine is commonly associated with: fat oxidation marketing; deficiency (renal dialysis). Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

N-acetylcysteine (NAC) is commonly associated with: mucolytic rx context; psychiatry adjunct trials; antioxidant precursor. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

NR (nicotinamide riboside) is commonly associated with: nad+ precursor trials; metabolic aging research. Our registry tags evidence as medium; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Ginseng is not one molecule; ginsenoside profiles differ by species and processing.

ALA has specific medical contexts (especially under supervision for neuropathy discussions); casual fat-loss marketing is weaker.

Traditional heart support; mild signals in blood pressure and CHF contexts; not a replacement for prescribed care. We summarize evidence, safety, and hype as editorial context-not medical advice.

Prebiotic fiber that feeds gut bacteria; regularity and microbiome signals in trials; gas and bloating if ramped quickly. We summarize evidence, safety, and hype as editorial context-not medical advice.

Niacin is a real vitamin; high-dose nicotinic acid is closer to a pharmacologic intervention than a casual multivitamin add-on.

Contains monacolin K; statin-like effects and risks; quality and labeling vary; clinician oversight advised. We summarize evidence, safety, and hype as editorial context-not medical advice.

Spirulina is food-like, not a chelation therapy.

Used for digestion and lipid support; cynarin and related compounds have human trial signal. We summarize evidence, safety, and hype as editorial context-not medical advice.

Plant sterol for cholesterol and BPH; meta-analyses support modest LDL reduction. We summarize evidence, safety, and hype as editorial context-not medical advice.

Choline compound used for cognitive support; some stroke-recovery and dementia trial data; nootropic marketing oversells. We summarize evidence, safety, and hype as editorial context-not medical advice.

Green tea as beverage is fine for most; concentrated extracts change risk profile.

NAC is not a harmless daily antioxidant for everyone at high doses.

Phospholipid for cell membranes and liver; some cognitive and lipid trial signals. We summarize evidence, safety, and hype as editorial context-not medical advice.

Quercetin is not a substitute for asthma controllers.

Bile acid used in liver and metabolic research; human supplement data are emerging but niche. We summarize evidence, safety, and hype as editorial context-not medical advice.

Vitamin K matters for clotting biology; K2-specific longevity claims are more exciting in theory than settled in trials.

Astaxanthin will not replace sunscreen.

Cinnamon type with lower coumarin; glucose and lipid signals in trials are modest. We summarize evidence, safety, and hype as editorial context-not medical advice.

Carnitine is not a stimulant fat burner for replete omnivores.

Milk thistle is not a hangover license.

SAM-e is not an OTC antidepressant replacement.

Colostrum is not infant formula replacement.

Chlorella does not remove heavy metals from your body in proven retail doses.

Ginkgo still appears in tinnitus and claudication discussions with mixed outcomes.

Arginine is real physiology; pills do not always recreate infusion physiology.

Lion's mane is fashionable in nootropic stacks; mycelium vs fruiting body debates affect potency.

MCT oil calories still count.

Metformin is evidence-based for type 2 diabetes; longevity claims in healthy adults are speculative and not standard care.

NR is not proven life extension in humans.

Blood pressure and metabolic interest; human trials exist but are smaller and varied. We summarize evidence, safety, and hype as editorial context-not medical advice.

PS is not a prescription cognitive drug.

Antioxidant extract with some circulatory and skin trial data; industry funding common. We summarize evidence, safety, and hype as editorial context-not medical advice.

Black pepper compound for bioavailability enhancement; modest trial support for absorption. We summarize evidence, safety, and hype as editorial context-not medical advice.

ALCAR crosses marketing lines between mitochondria cosplay and real neuropathy adjuvants.

Acetyl-L-carnitine is commonly associated with: cognition marketing; neuropathy adjunct research. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Agmatine sulfate is commonly associated with: pump/nitric oxide antagonist paradox marketing; mood niche. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Traditional remedy with antioxidant and metabolic interest; human trial quality varies widely. We summarize evidence, safety, and hype as editorial context-not medical advice.

Black seed oil (Nigella sativa) is commonly associated with: glucose/lipid small trials; immune marketing. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Borage oil (GLA) is commonly associated with: skin/inflammation marketing. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Capsaicin is not a pain-free fat loss switch.

Dipeptide for aging and exercise; eye and cognitive interest; human data are mixed. We summarize evidence, safety, and hype as editorial context-not medical advice.

CLA (conjugated linoleic acid) is commonly associated with: body composition marketing. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

DIM (diindolylmethane) is commonly associated with: estrogen metabolism marketing. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Evening primrose oil (GLA) is commonly associated with: eczema/pms marketing. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Fenugreek is not domperidone for lactation.

Fisetin is commonly associated with: senolytic marketing from rodent hype; antioxidant. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

GABA (oral supplement) is commonly associated with: calm/sleep marketing. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Glutathione (oral / liposomal) is commonly associated with: detox marketing; skin lightening illegal/off-label risks in some regions. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Oral HA is not dermal filler in a capsule.

Lycopene is commonly associated with: prostate marketing; antioxidant. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

NAD+ (IV/clinic marketing) is commonly associated with: clinic infusion wellness trends. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

NMN (nicotinamide mononucleotide) is commonly associated with: nad+ precursor marketing; longevity stacks. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

PEA (palmitoylethanolamide) is commonly associated with: neuropathic pain niche trials; anti-inflammatory marketing. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.

Resveratrol is a cautionary lesson in exciting animal science with underwhelming human outcome replication so far.

Berry oil rich in fatty acids; skin and lipid claims; human data are growing but uneven. We summarize evidence, safety, and hype as editorial context-not medical advice.

Sulforaphane / glucoraphanin (broccoli sprout extracts) is commonly associated with: nrf2 / detox marketing; air pollution small human pilots. Our registry tags evidence as low; this hub translates that into an ingredient-level verdict with safety and hype context - not individualized recommendations.