Overview
Safety in plain terms
Side effects and interactions depend on medications and conditions; involve clinicians for pregnancy, bleeding risk, and polypharmacy.
Tolerability
Commonly reported effects
- Variable by person and dose
Higher-risk contexts
Who should pause or get medical guidance first
- Self-experimentation
- Pregnancy
- Major surgery without disclosure
Polypharmacy
Interactions & cautions
- Many drugs-disclose all supplements to prescribers
Practical
Dose context (not a prescription)
Use labeled directions unless a clinician tailors dosing; stop and seek care for allergic reactions.
Our editorial safety score is 52/100 - methodology and limitations are on the full hub page.
Verdict context
Safety, interactions, or risk profiles deserve extra scrutiny; involve a clinician before experimenting.
Same ingredient, other questions
Focused pages for common searches about St. John's wort. Each uses the same underlying evidence file with a different lens.
Explore further
A few hand-picked entry points around St. John's wort: categories, answers to narrow questions, and comparisons.
Category hubs
Related ingredients
Ingredients we group near St. John's wort in our model - not interchangeable, but often read together.
- Magnesium78/100Promising
A common shortfall nutrient with roles in muscle and nerve function; certain forms help constipation; sleep claims are softer.
- Melatonin76/100Promising
A chronobiotic hormone useful for circadian issues and some sleep onset problems; not a sedative for everyone.
- Senna74/100Promising
Occasional constipation; Detox teas (problematic chronic use). Typical label framing: OTC protocols short term; chronic misuse harmful.
Alternatives
Swaps people discuss alongside St. John's wort - still judge each ingredient on its own evidence.