Stack analysis
Milk thistle + NAC + glutathione
‘Liver detox’ and antioxidant stacks common in wellness retail.
Confidence
57/100
Registry ingredients
Structured entries from our supplement intelligence registry (not personalized recommendations).
- Milk thistle (silymarin)herb
Evidence tier: medium·Typical label range: Extracts often 200-600 mg/day products.
- N-acetylcysteine (NAC)compound
Evidence tier: medium·Typical label range: Supplement often 600-1200 mg/day; Rx doses higher in acetaminophen protocols.
- Glutathione (oral / liposomal)compound
Evidence tier: low·Typical label range: Bioavailability of non-liposomal oral debated; liposomal marketing strong.
What this stack claims
Improved liver enzymes, toxin clearance, hangover prevention - often asserted without matching evidence for healthy livers.
Biological logic
NAC replenishes glutathione in acetaminophen toxicity protocols (medical). Silymarin has mixed trial history. Oral glutathione’s systemic bioavailability is debated; liposomal marketing outpaces consensus.
Evidence level
Registry tier for this stack: LOW
This triple is coherent as a brand story, not as a proven universal liver upgrade. If enzymes are abnormal, the answer is diagnosis - not stacks.
Risks
Bleeding/nitroglycerin interaction (NAC); allergy; masking alcohol use disorder harms; wasted spend; rare liver injury with some herbal products/adulterants.
Final verdict
**Weak for general ‘detox’ goals.** NAC has real medical contexts; this retail bundle mostly sells reassurance.
FAQ
- Does this help after drinking?
- If you have unhealthy drinking patterns, medical care matters. Supplements are not a safety net.
- Should I take NAC daily forever?
- Long-term casual use should have a reason; discuss with a clinician if you have pulmonary, psychiatric, or cardiovascular medication plans.
- Is liposomal glutathione proven better?
- Some products show biomarker shifts; clinical outcome superiority is not settled across populations.